Identifiability and estimation of causal effects in randomized trials with noncompliance and completely nonignorable missing data.

Discussion of "Identifiability and estimation of causal effects in randomized trials with noncompliance and completely nonignorable missing data".

Multiple imputation methods for treatment noncompliance and nonresponse in randomized clinical trials.

Randomized clinical trials are a powerful tool for investigating causal treatment effects, but in human trials there are oftentimes problems of noncompliance which standard analyses, such as the intention-to-treat or as-treated analysis, either ignore or incorporate in such a way that the resulting estimand is no longer a causal effect. One alternative to these analyses is the complier average ...

Identification of causal effects on binary outcomes using structural mean models

Structural mean models (SMMs) were originally formulated to estimate causal effects among those selecting treatment in randomized controlled trials affected by nonignorable noncompliance. It has already been established that SMMs can identify these causal effects in randomized placebo-controlled trials under fairly weak assumptions. SMMs are now being used to analyze other types of study where ...

Efficient nonparametric estimation of causal effects in randomized trials with noncompliance

Causal approaches based on the potential outcome framework provide a useful tool for addressing noncompliance problems in randomized trials. We propose a new estimator of causal treatment effects in randomized clinical trials with noncompliance. We use the empirical likelihood approach to construct a profile random sieve likelihood and take into account the mixture structure in outcome distribu...

Methods for clustered encouragement design studies with noncompliance and missing data.

Encouragement design studies are particularly useful for estimating the effect of an intervention that cannot itself be randomly administered to some and not to others. They require a randomly selected group receive extra encouragement to undertake the treatment of interest, where the encouragement typically takes the form of additional information or incentives. We consider a "clustered encour...